Interference with thyroid hormone activity is often one of the basic causes of hypothyroidism, which, in turn, is responsible for more than 100 different symptoms, not the least of which is otherwise unexplained weight gain.
Commonly observed symptoms include:
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Fatigue
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Dry Skin
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Constipation
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Intolerance to Cold/Heat
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Muscle Weakness
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Indigestion
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Memory Loss
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Menstrual Disorders
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Unopposed oestrogen (oestrogen dominance) can interfere with thyroid hormone activity and is often an underlying cause of thyroid disfunction. Because oestrogen and thyroid hormone have opposing actions, probably at the thyroid hormone receptor level, unopposed oestrogen will prevent the thyroid hormone from "completing its mission", resulting in "hypothyroid symptoms" despite normal serum levels of thyroid hormone.
Conversely, progesterone re-directs the activity of oestrogen by increasing the sensitivity of oestrogen receptors and, most importantly, inhibits many of oestrogen's undesirable side effects, which includes interference with thyroid hormone activity.